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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 524262Generated: October 29, 2026

2-(Trifluoromethoxy)benzoic acid → HCID 67365557, compound

https://huagongshe.com/reaction/524262

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Trifluoromethoxy)benzoic acidHCID 2777223—
Reactant5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochlorideHCID 66616406—
ProductHCID 67365557HCID 67365557—

Reaction Steps

The title compound is prepared analogously as described for GP2-WU2 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1) and 2-(trifluoromethoxy)benzoic acid as starting compounds. The crude product is purified by chromatography (amino phase silica gel and DCM) and by crystallization from DCM and diethyl ether to yield the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09340522B2
Source datasetuspto-grants-2016_05
ORD IDord-f38c9c092c3f4d4ea3bace54685bc02e
Source noteuspto-grants-2016_05