HRID524266

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID608722

1-Methoxy-2-naphthoic acid

C12H10O3

结构：COc1ccc(C2=NN(C3CCNCC3)C(=O)C2(C)C)cc1OC.Cl

HCID66616406

未命名化合物

2 次

PRODUCTS

生成物

结构：COc1ccc(C2=NN(C3CCN(C(=O)c4ccc5ccccc5c4OC)CC3)C(=O)C2(C)C)cc1OC

HCID67363933

5-(3,4-Dimethoxyphenyl)-2-{1-[(1-methoxynaphthalen-2-yl)carbonyl]piperidin-4-yl}-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one

C30H33N3O5

PROCEDURE

实验过程

The title compound is prepared analogously as described for GP2-WU2 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1) and 1-methoxynaphthalene-2-carboxylic acid as starting compounds. The crude product is purified by chromatography (amino phase silica gel and DCM) and by crystallization from diethyl ether to yield the title compound.

WORKUP

后处理

customThe title compound is prepared analogously
customThe crude product is purified by chromatography (amino phase silica gel and DCM) and by crystallization from diethyl ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-85e0734ea05444bfab8929ac06bb9627
来源数据集: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09340522B2
来源说明: uspto-grants-2016_05

反应 SMILES

Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:12]2[C:13]([CH3:25])([CH3:24])[C:14](=[O:23])[N:15]([CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11].[CH3:26][O:27][C:28]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH:31]=[CH:30][C:29]=1[C:38](O)=[O:39]>>[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:12]2[C:13]([CH3:25])([CH3:24])[C:14](=[O:23])[N:15]([CH:17]3[CH2:22][CH2:21][N:20]([C:38]([C:29]4[CH:30]=[CH:31][C:32]5[C:37](=[CH:36][CH:35]=[CH:34][CH:33]=5)[C:28]=4[O:27][CH3:26])=[O:39])[CH2:19][CH2:18]3)[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]