HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-methylquinoline-2-carboxylic acid → HCID 67366470, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-methylquinoline-2-carboxylic acid | HCID 748357 | — |
| Reactant | 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride | HCID 66616406 | — |
| Product | HCID 67366470 | HCID 67366470 | — |
Reaction Steps
The title compound is prepared analogously as described for GP2-WU2 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one (compound B1) and 4-methylquinoline-2-carboxylic acid as starting compounds. The crude product is purified by chromatography (amino phase silica gel and DCM) and by crystallization from methanol to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340522B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-06dae3703da849dd96cf395799044f07 |
| Source note | uspto-grants-2016_05 |