HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(Benzyloxy)-2-methylbenzoic acid → HCID 67364130, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(Benzyloxy)-2-methylbenzoic acid | HCID 59760047 | — |
| Reactant | 5-(7-methoxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-4-yl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one hydrochloride | HCID 66616590 | — |
| Product | HCID 67364130 | HCID 67364130 | — |
Reaction Steps
The title compound is prepared analogously as described for GP2-WU2 using 5-(7-methoxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-4-yl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one (compound B5) and 5-(benzyloxy)-2-methylbenzoic acid (compound F1) as starting compounds. The crude product is purified by chromatography (amino phase silica gel and DCM) and by crystallization from DCM and diethyl ether to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340522B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-372c3862874340958641849566a0bbb9 |
| Source note | uspto-grants-2016_05 |