HCID 13067254, compound → HCID 67378264, compound

HRID 524277Notes

Reaction equation

HRID 524277 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:12]2[C:13]([CH3:25])([CH3:24])[C:14](=[O:23])[N:15]([CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)[N:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11].[Br:26][C:27]1[CH:28]=[CH:29][CH:30]=[C:31]2[C:36]=1[C:35]([C:37](Cl)=[O:38])=[CH:34][CH:33]=[CH:32]2>>[Br:26][C:27]1[CH:28]=[CH:29][CH:30]=[C:31]2[C:36]=1[C:35]([C:37]([N:20]1[CH2:21][CH2:22][CH:17]([N:15]3[C:14](=[O:23])[C:13]([CH3:25])([CH3:24])[C:12]([C:6]4[CH:7]=[CH:8][C:9]([O:10][CH3:11])=[C:4]([O:3][CH3:2])[CH:5]=4)=[N:16]3)[CH2:18][CH2:19]1)=[O:38])=[CH:34][CH:33]=[CH:32]2

Participants

3

Reactant 2

HCID 13067254HCID 13067254, compoundHCID 666164065-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride2×

Product 1

HCID 67378264HCID 67378264, compound

Procedure

The title compound is prepared analogously as described for GP1 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one hydrochloride (compound B1*HCl) and 8-bromonaphthalene-1-carbonyl chloride as starting compounds. The crude product is purified by crystallization from EA and diethyl ether to yield the title compound.

Workup

  1. customThe title compound is prepared analogously
  2. customThe crude product is purified by crystallization from EA and diethyl ether

Sources & evidence

ORD record
ord-4f20ff9ce5084f80b108a154eb0e78ad
Source dataset
uspto-grants-2016_05
Patent number
US09340522B2

Reaction notes

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