1-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine → HCID 66616512, compound

HRID 524296Notes

Reaction equation

HRID 524296 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:17]2[C:18]([CH3:24])([CH3:23])[C:19](=[O:22])[NH:20][N:21]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CC1C=CC(S(O[CH:36]2[CH2:41][CH2:40][N:39](C(OC(C)(C)C)=O)[CH2:38][CH2:37]2)(=O)=O)=CC=1>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:17]2[C:18]([CH3:24])([CH3:23])[C:19](=[O:22])[N:20]([CH:36]3[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]3)[N:21]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 157347131-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine2×HCID 666165693-[3-(benzyloxy)-4-methoxyphenyl]-4,4-dimethyl-4,5-dihydro-1H-pyrazol-5-one2×

Product 1

HCID 66616512HCID 66616512, compound

Procedure

Prepared analogously as described for the example B1 (Alternative 1) using 5-[3-(benzyloxy)-4-methoxyphenyl]-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one (compound C4) and tert-butyl 4-{[(4-methylphenyl)sulfonyl]oxy}piperidine-1-carboxylate (compound E1) as starting compounds resulting in the hydrochloride salt of the title compound. (compound B4*HCl)

Workup

  1. customPrepared analogously

Sources & evidence

ORD record
ord-c08a9154d02a407e965146b9438e061d
Source dataset
uspto-grants-2016_05
Patent number
US09340522B2

Reaction notes

Loading…