1-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine → HCID 66616532, compound

HRID 524302Notes

Reaction equation

HRID 524302 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C:15]3([CH2:19][CH2:18][CH2:17][CH2:16]3)[C:14](=[O:20])[NH:13][N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].CC1C=CC(S(O[CH:32]2[CH2:37][CH2:36][N:35](C(OC(C)(C)C)=O)[CH2:34][CH2:33]2)(=O)=O)=CC=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C:15]3([CH2:16][CH2:17][CH2:18][CH2:19]3)[C:14](=[O:20])[N:13]([CH:32]3[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]3)[N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 157347131-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine2×HCID 66616507HCID 66616507, compound

Product 1

HCID 66616532HCID 66616532, compound

Procedure

Prepared analogous as described for the example B1 (Alternative 1) using 4-(3,4-dimethoxyphenyl)-2,3-diazaspiro[4.4]non-3-en-1-one (compound C10) and tert-butyl 4-{[(4-methylphenyl)sulfonyl]oxy}piperidine-1-carboxylate (compound E1) as starting compounds resulting in the hydrochloride salt of the title compound. (compound B10*HCl)

Workup

  1. customPrepared analogous

Sources & evidence

ORD record
ord-774349c8b438431488eac6c3673c5c89
Source dataset
uspto-grants-2016_05
Patent number
US09340522B2

Reaction notes

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