反应详情

To a solution of 4-hydroxy-6-methyl-nicotinic acid (10.00 g, 65.3 mmol) in glacial acetic acid (35 mL) is added bromine (4.00 mL, 78.1 mmol). After stirring for 18 h at room temperature, additional bromine (0.5 mL) is added and the reaction mixture is stirred for an additional 24 h. The reaction mixture is evaporated under reduced pressure and the remaining residue is co-evaporated with toluene. The remaining residue is treated with a small amount of MeOH and then triturated with water. The precipitate is filtered off and dried. Yield: 13.8 g (92% of theory); ESI mass spectrum: [M+H]+=232 (bromine isotope pattern); Retention time HPLC: 0.61 min (Z002_002).

1. stirringthe reaction mixture is stirred for an additional 24 h
2. customThe reaction mixture is evaporated under reduced pressure
3. additionThe remaining residue is treated with a small amount of MeOH
4. customtriturated with water
5. filtrationThe precipitate is filtered off
6. customdried
7. custom0.61 min (Z002_002)