化工社化工社 化学情報印刷レポート · 研究参考用
Bromine → 5-Bromo-1-cyclobutyl-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid (5-methanesulfonyl-pyridin-2-ylmethyl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 4-Methylsulfonylbenzylamine hydrochloride | HCID 2729269 | — |
| 反応物 | (5-(Methylsulfonyl)pyridin-2-yl)methanamine | HCID 57354332 | — |
| 反応物 | 5-Bromo-1-isopropyl-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid | HCID 86711577 | — |
| 反応物 | 5-Bromo-1-cyclobutyl-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid | HCID 86711582 | — |
| 生成物 | 5-Bromo-1-cyclobutyl-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid (5-methanesulfonyl-pyridin-2-ylmethyl)-amide | HCID 86711581 | — |
反応手順
Preparation 18 is prepared following the procedure for preparation 5, substituting preparation 3c with preparation 7b and 4-methylsulfonylbenzylamine hydrochloride with C-(5-methanesulfonyl-pyridin-2-yl)-methylamine. ESI mass spectrum: [M+H]+=454 (bromine isotope pattern); Retention time HPLC: 1.14 min (Z002_006).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09340507B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-aff637d6df194ea29ec0e7bda4d65b3e |
| 出典メモ | uspto-grants-2016_05 |