HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → (R)-5-Bromo-1-sec-butyl-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid (5-methanesulfonyl-pyridin-2-ylmethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 4-Methylsulfonylbenzylamine hydrochloride | HCID 2729269 | — |
| Reactant | (5-(Methylsulfonyl)pyridin-2-yl)methanamine | HCID 57354332 | — |
| Reactant | 5-Bromo-1-isopropyl-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid | HCID 86711577 | — |
| Reactant | (R)-5-Bromo-1-sec-butyl-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid | HCID 86711584 | — |
| Product | (R)-5-Bromo-1-sec-butyl-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid (5-methanesulfonyl-pyridin-2-ylmethyl)-amide | HCID 86711583 | — |
Reaction Steps
Preparation 19 is prepared following the procedure for preparation 5, substituting preparation 3c with preparation 11b and 4-methylsulfonylbenzylamine hydrochloride with C-(5-methanesulfonyl-pyridin-2-yl)-methylamine. ESI mass spectrum: [M+H]+=456 (bromine isotope pattern); Retention time HPLC: 0.87 min (Z018_S04).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340507B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-38efb19c1fca4d8fbb19efb3456a7c22 |
| Source note | uspto-grants-2016_05 |