Phthalic Anhydride → HCID 86711603, compound

Participants

Reaction Steps

A mixture of 2-fluoro-4-methylsulfanyl-benzylamine (preparation 34a, 10.0 g, 52.6 mmol) and phthalic anhydride (7.94 g, 52.6 mmol) in toluene (510 mL) is heated at reflux over night. All volatiles are removed under reduced pressure, and the residue is recrystallized from hot ethanol. Yield: 9.2 g (55% of theory); ESI mass spectrum: [M+Na]+=302; Retention time HPLC: 0.67 min (X012_S01).

Provenance & Evidence