反应详情

A mixture of 4-(3-morpholin-4-yl-quinoxalin-6-yl)-phenylamine [Intermediate Example 4.1] (100 mg) in dichloromethane (3.3 mL) was cooled (ice bath) and treated with cyclopropyl isocyanate (30 mg, 0.36 mmol) and stirred at room temperature for 3 days. The resulting precipitate was filtered, washed with dichloromethane and dried to give the title compound (96 mg). UPLC-MS: RT=1.01 min; m/z (ES+) 390.24 [MH+]; required MW=389.46.

1. temperaturewas cooled (ice bath)
2. filtrationThe resulting precipitate was filtered
3. washwashed with dichloromethane
4. customdried