2,4-Difluoroaniline → Ethyl 2-(4-cyclopropylsulfonylphenyl)-2-(2,4-difluoroanilino)acetate

Participants

Reaction Conditions

Reaction Steps

Ethyl 2-bromo-2-(4-cyclopropylsulfonylphenyl)acetate (0.8 g, 2.30 mmol) [obtained as described in WO2009/047798 A2; Example A1] and 2,4-difluoroaniline (3.0 mL) mixed together and heated at 150° C. in a seal tube for 12 hrs. Reaction mixture was cooled to rt and purified by column chromatography using 20% ethyl acetate in hexane as eluent to provide ethyl 2-(4-cyclopropylsulfonylphenyl)-2-(2,4-difluoroanilino)acetate (0.65 g).

Provenance & Evidence