Lithium Hydroxide → (4-Cyclopropanesulfonyl-phenyl)-[(tetrahydro-pyran-4-yloxy)]-acetic acid

Participants

Reaction Steps

To a stirred solution of intermediate 2-[4-(Cyclopropanesulfonyl)phenyl]-2-(tetrahydro-pyran-4-yloxy)acetic acid ethyl ester (8.0 g, 21 mmol) in tetrahydrofuran (80 mL) was added a solution of LiOH (2.27 g in 40 mL of water, 54 mmol) at 25° C. and stirred for 2 h. Completion of reaction was confirmed by TLC. Organic solvent was removed under reduced pressure. The aqueous layer was acidified to pH 2-3 using 1 N HCl. White solid obtained was filtered through Buchner funnel dried under vacuum to afford pure product.

Provenance & Evidence