Cesium carbonate → HCID 68182358, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-Nitro-1H-pyrazole (0.265 gm, 2.34 mmol), tert-butyl 6-chloropyridine-3-carboxylate (0.500 gm, 2.34 mmol) was dissolved in anhydrous DMF (10 mL). Cesium carbonate (1.90 gm, 5.86 mmol) was added and reaction mixture was heated at 100° C. for 6 h. The reaction mixture was cooled to room temperature and poured into ice water, a white precipitate formed was filtered and dried under vacuum to give tert-butyl 6-(3-nitropyrazol-1-yl)pyridine-3-carboxylate (0.505 gm).

Provenance & Evidence