HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 4-[(4,4-Dimethyl-2-iso-propoxy-3,4-dihydro-6-quinolinyl)ethynyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Ethyl 4-[(4,4-dimethyl-2-isopropoxy-3,4-dihydro-6-quinolinyl)ethynyl]benzoate | HCID 19963721 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[(4,4-Dimethyl-2-iso-propoxy-3,4-dihydro-6-quinolinyl)ethynyl]benzoic acid | HCID 19963705 | — |
Reaction Steps
A solution of 0.023 mg (0.06 mmol) of ethyl 4-[(4,4-dimethyl-2-iso-propoxy-3,4-dihydro-6-quinolinyl)ethynyl]benzoate (Compound 6) in 2 ml of THF, 1 ml of EtOH, and 2 ml of 1N LiOH was stirred at room temperature for 1 h. Aqueous work up yielded the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05616712 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-7e8e49eeb297495fb93b3e4ce87c807a |
| Source note | uspto-grants-1997_04 |