HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-[(4,4-dimethyl-2-methylthio-3,4-dihydro-6-quinolinyl)ethynyl]benzoate → 4-[(4,4-Dimethyl-2-methylthio-3,4-dihydro-6-quinolinyl)ethynyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-[(4,4-dimethyl-2-methylthio-3,4-dihydro-6-quinolinyl)ethynyl]benzoate | HCID 19963703 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Lithium Hydroxide | HCID 3939 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[(4,4-Dimethyl-2-methylthio-3,4-dihydro-6-quinolinyl)ethynyl]benzoic acid | HCID 19963731 | — |
Reaction Steps
A solution of 0.100 g (0.30 mmol) of ethyl 4-[(4,4-dimethyl-2-methylthio-3,4-dihydro-6-quinolinyl)ethynyl]benzoate (Compound 9) in 2 ml of THF, 1 ml of EtOH and 2 ml of 1N LiOH was stirred at room temperature for 1 h, followed by aqueous work up to yield the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05616712 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-6d7e8b1ba72f411199edb6ae384d2761 |
| Source note | uspto-grants-1997_04 |