HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 56591547, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | [1,3]Thiazolo[5,4-b]pyridin-2-amine | HCID 592050 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 66616552 | HCID 66616552 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 56591547 | HCID 56591547 | 21.6% |
Reaction Steps
The compound of example A4 was obtained by similar method described in example A2 using 2-(4-morpholinosulfonylphenyl)-2-tetrahydropyran-4-yloxy-acetic acid (Preparation 11, 0.1 g, 0.25 mmol), thiazolo[5,4-b]pyridin-2-ylamine (0.050 g, 0.31 mmol), HOBt (0.042 g, 0.31 mmol), and EDCl (0.060 g, 0.31 mmol), N-methyl morpholine (0.065 g, 0.64 mmol) in DMF (5 mL) to provide the title compound (0.028 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340506B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-3ab875686d394a8bb4297d5538e5cff4 |
| Source note | uspto-grants-2016_05 |