HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 68182436, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | Ethyl (6-aminopyridin-2-yl)acetate | HCID 13060163 | — |
| Reactant | HCID 59610020 | HCID 59610020 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68182436 | HCID 68182436 | 46.2% |
Reaction Steps
The compound of example A9 was obtained by similar method described in example A1 using 2-(4-cyclopropanesulfonyl-phenyl)-2-[(tetrahydro-pyran-4-yloxy)]-acetic acid (Preparation 4; 0.990 g, 2.91 mmol), ethyl 2-(6-amino-2-pyridyl)acetate (0.35 g, 1.94 mmol), HOBt (0.65 g, 4.81 mmol), and EDCl (0.92 g, 4.81 mmol), N-methyl morpholine (0.64 mL, 5.83 mmol) in DMF (25 mL) to provide the title compound (0.45 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340506B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-e9794456b97c4157bd63aa5b06468b68 |
| Source note | uspto-grants-2016_05 |