HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 86669557, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 59404898 | HCID 59404898 | — |
| Reactant | HCID 68182481 | HCID 68182481 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86669557 | HCID 86669557 | 42.9% |
Reaction Steps
The compound of example A10 was obtained by similar method described in example A1 using 2-(6-cyclopentylsulfonyl-3-pyridyl)-2-tetrahydropyran-4-yloxy-acetic acid (Preparation 14; 0.200 g, 0.542 mmol), methyl 3-(2-aminothiazol-5-yl)oxybenzoate (Preparation 20, 0.162 g, 0.650 mmol), HOBt (0.087 g, 0.650 mmol), and EDCl (0.124 g, 0.650 mmol), N-methyl morpholine (0.136 g, 1.35 mmol) in DCM (8 mL) to provide the title compound (0.140 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340506B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-14480fe8382f44f2b25e22a80fc2e672 |
| Source note | uspto-grants-2016_05 |