Sodium borohydride → HCID 86669560, compound

Participants

Reaction Steps

To a stirred solution of 2-(4-Cyclopropanesulfonyl-phenyl)-N-[5-(4-formyl-phenoxy)-thiazol-2-yl]-2-(tetrahydro-pyran-4-yloxy)-acetamide (Example A74; 0.2 g, 0.36 mmol) in 10 mL methanol, sodium borohydride (0.027 g, 0.73 mmol) was added in portions at 0° C. After complete addition reaction mixture was stirred for 1 hr at 0° C. to 10° C. Completion of the reaction was confirmed by TLC, then methanol was evaporated on rotavapour. Reaction mixture was diluted with ethyl acetate (3×20 mL), organic layer was washed with water and brine, dried (Na2SO4) and concentrated in vacuo. Purified by PREP TLC to afford title compound (0.110 g).

Provenance & Evidence