Tributylvinyltin → HCID 86669566, compound

Participants

Reaction Steps

To mixture of N-(5-Bromo-thiazolo[5,4-b]pyridin-2-yl)-2-(4-cyclopropanesulfonyl-phenyl)-2-(tetrahydro-pyran-4-yloxy)-acetamide (Example-A95) (0.135 g, 0.24 mmol), Pd(PPh3)4 (0.014 g, 0.012 mmol) and LiCl (0.031 g, 0.73 mmol) in THF:DMF (1:1, 5 mL) under inert atmosphere was added tributyl(vinyl)stannane (0.23 g, 0.73 mmol) and heated under reflux for 8 hrs. Solvent was removed in vacuo and taken into brine and extracted with ethyl acetate (3×5 mL), washed with water and brine, dried (Na2SO4) and concentrated in vacuo to afford titled compound (0.080 g)

Provenance & Evidence