Trifluoroacetic acid → HCID 86575087, compound

Participants

Reaction Steps

To a solution of 1-tert-butyl 4-((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3a-((E)-3-oxo-3-(p-tolylamino)prop-1-en-1-yl)-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 2,2-dimethylsuccinate (250 mg, 0.325 mmol) in dichloromethane (5 mL) stirred at rt was added TFA (0.025 mL, 0.325 mmol). The reaction mixture was stirred at rt for 1 h. Upon completion and work-up and purification the title compound was obtained as a trifluoroacetic acid salt (150 mg, 0.181 mmol, 55.8%) as a light white solid. 1H NMR (300 MHz, DMSO-d6) δ=9.70 (s, 1H), 7.51 (d, J=8.4 Hz, 2H), 7.11 (d, J=8.4 Hz, 2H), 6.83 (d, J=15.8 Hz, 1H), 6.08 (d, J=15.7 Hz, 1H), 4.53-4.32 (m, 1H), 3.30-3.11 (m, 1H), 2.90-2.73 (m, 1H), 2.55-2.51 (m, 1H), 2.35-0.75 (m, 51H); LC/MS: m/z calculated 713.5. Found 714.3 (M+1)+.

Provenance & Evidence