Trifluoroacetic acid → HCID 71611309, compound

Participants

Reaction Steps

To a solution of 1-tert-butyl 4-((3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-((E)-3-((1-(5-chloropyrimidin-2-yl)cyclopropyl)amino)-3-oxoprop-1-en-1-yl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-9-yl) 2,2-dimethylsuccinate (300 mg, 0.360 mmol) in dichloromethane (5 mL) stirred at rt was added TFA (5 mL). The reaction mixture was stirred at rt for 2 h. It was evaporated in vacuo to give crude product which was purified by preparative HPLC to give the title compound (90 mg, 28%) as a light yellow solid. 1H NMR (300 MHz, DMSO-d6) δ=8.72 (s, 2H), 8.54 (br. s., 1H), 6.70 (d, J=15.8 Hz, 1H), 5.94 (d, J=15.8 Hz, 1H), 4.55-4.29 (m, 1H), 3.31-3.07 (m, 1H), 2.94-2.64 (m, 1H), 2.59-0.60 (m, 52H); LC/MS: m/z calculated 775.4. Found 776.3 (M+1)+.

Provenance & Evidence