反应详情

4-Chloroaniline (15 g, 117 mmol) and formic acid (25 mL, 663 mmol) were heated to reflux for 2 hours. The mixture was concentrated in vacuo. Saturated aqueous sodium hydrogen carbonate was added and the aqueous phase was extracted twice with ethyl acetate. The combined organic phases were dried over magnesium sulphate, filtered and concentrated in vacuo to give N-(4-chloro-phenyl)-formamide (17.6 g, 97%) as a grey crystalline compound.

1. temperatureto reflux for 2 hours
2. concentrationThe mixture was concentrated in vacuo
3. additionSaturated aqueous sodium hydrogen carbonate was added
4. extractionthe aqueous phase was extracted twice with ethyl acetate
5. dry with materialThe combined organic phases were dried over magnesium sulphate
6. filtrationfiltered
7. concentrationconcentrated in vacuo