Cyclohexylamine → HCID 178478389, compound

HRID 524511Notes

Reaction equation

HRID 524511 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.[CH:12]1([NH2:18])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>C(#N)C>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([NH:18][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)[N:3]=1

Participants

4

Reactant 2

HCID 7965CyclohexylamineHCID 53244122,6-Dichloropurine

Product 1

HCID 178478389HCID 178478389, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
50 °C

Procedure

2,6-Dichloropurine (2.5 g, 13.23 mmol) and cyclohexylamine (1.51 mL, 13.2 mmol) were dissolved in acetonitrile (25 mL) and heated to 50° C. for 5 days. The white precipitate was collected by filtration and used without further purification.

Workup

  1. filtrationThe white precipitate was collected by filtration
  2. customused without further purification

Sources & evidence

ORD record
ord-37587026b91945b394423b755062c03e
Source dataset
uspto-grants-2016_05
Patent number
US09340544B2

Reaction notes

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