HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine-3-carboxylic acid hydrochloride → HCID 73295971, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine-3-carboxylic acid hydrochloride | HCID 45790954 | — |
| Reactant | 6-Bromomethyl-4-(2-chloro-4-fluoro-phenyl)-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester | HCID 89995963 | — |
| Product | HCID 73295971 | HCID 73295971 | 46% |
Reaction Steps
Methyl 6-(bromomethyl)-4-(2-chloro-4-fluorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (2.94 g, 6.6 mmol) (The compound was synthesized according to the procedure as described in WO2010069147A) was reacted with morpholine-3-carboxylic acid hydrochloride (1.1 g, 6.6 mmol) according to the procedure as described in Example 3 to give the title compound as a yellow solid (1.5 g, 46%). The compound was characterized by the following spectroscopic data:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340538B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-8dafada4cab147b4b834e2612edb0159 |
| Source note | uspto-grants-2016_05 |