Morpholine-3-carboxylic acid hydrochloride → 4-((6-(2,4-Dichlorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholine-3-carboxylic acid

참여 물질

반응 단계

Methyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (3.02 g, 6.54 mmol) (The compound was synthesized according to the procedure as described in WO2010069147A) was reacted with morpholine-3-carboxylic acid hydrochloride (1.1 g, 6.54 mmol) according to the procedure as described in Example 3 to give the title compound as a yellow solid (1.5 g, 45%). The compound was characterized by the following spectroscopic data:

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