反应详情

Ethyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (0.24 g, 0.51 mmol) was reacted with (S)-6,6-dimethyl morpholine-3-carboxylic acid hydrochloride (0.1 g, 0.51 mmol) according to the procedure as described in Example 1, Step C to give the title compound as a yellow solid (0.19 g, 68%). The compound was characterized by the following spectroscopic data: