HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-morpholine-3-carboxylic acid → HCID 90043482, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-morpholine-3-carboxylic acid | HCID 1501894 | — |
| Reactant | Ethyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate | HCID 118107510 | — |
| Product | HCID 90043482 | HCID 90043482 | 80.2% |
Reaction Steps
Ethyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (1.6 g, 3.37 mmol) was reacted with (S)-morpholine-3-carboxylic acid (0.44 g, 3.37 mmol) according to the procedure as described in Example 28 to give the title compound as a yellow solid (1.42 g, 80%). The compound was characterized by the following spectroscopic data:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340538B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-61f11415ddec4a9d9a82b7a16f9777b7 |
| Source note | uspto-grants-2016_05 |