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HRID524606

反应详情

EQUATION

反应方程式

HRID 524606 的结构方程式

REACTANTS

反应物

2
结构：C[C@H]1OCCN[C@@H]1C(=O)O
HCID45791333

(2R,3S)-2-Methylmorpholine-3-carboxylic acid

C6H11NO3

结构：COC(=O)C1=C(CBr)NC(c2nccs2)=NC1c1ccc(Cl)cc1Cl
HCID118107550

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)C1=C(CN2CCO[C@H](C)[C@H]2C(=O)O)NC(c2nccs2)=NC1c1ccc(Cl)cc1Cl
HCID73295637

未命名化合物

收率 51.1%

PROCEDURE

实验过程

Methyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (0.88 g, 1.9 mmol) was reacted with (2R,3S)-2-methylmorpholine-3-carboxylic acid (0.28 g, 1.9 mmol) according to the procedure as described in Example 34 to give the title compound as a yellow solid (0.51 g, 51%). The compound was characterized by the following spectroscopic data: