N-bromobutanimide → Ethyl 6-(bromomethyl)-4-(2-chloro-4-fluorophenyl)-1-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	N-bromobutanimide	HCID 67184	—
Reactant	Ethyl 4-(2-chloro-4-fluorophenyl)-1,6-dimethyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate	HCID 90042905	—
Product	Ethyl 6-(bromomethyl)-4-(2-chloro-4-fluorophenyl)-1-methyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate	HCID 118107629	40%

Reaction Steps

Ethyl 4-(2-chloro-4-fluorophenyl)-1,6-dimethyl-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (0.4 g, 1.02 mmol) was reacted with NBS (0.2 g, 1.12 mmol) according to the procedure as described in Example 1, Step B to give the title compound as yellow oil (0.19 g, 40%). The compound was characterized by the following spectroscopic data:

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09340538B2
Source dataset	uspto-grants-2016_05
ORD ID	ord-b04219807dcc42b8a572012d01768f13
Source note	uspto-grants-2016_05