(S)-morpholine-3-carboxylic acid → (3S)-4-((5-(ethoxycarbonyl)-6-(5-fluoro-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholine-3-carboxyli c acid

Participants

Reaction Steps

Ethyl 6-(bromomethyl)-4-(5-fluoro-4′-(trifluoromethyl)-[1,1′-biphenyl]-2-yl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (3 g, 5.3 mmol) was reacted with (S)-morpholine-3-carboxylic acid (0.69 g, 5.3 mmol) according to the procedure as described in Example 1, Step C to give the title compound as a yellow solid (1.64 g, 50%). The compound was characterized by the following spectroscopic data:

Provenance & Evidence