3,5-Bis-trifluoromethylphenylboronic acid → 5-Fluoro-3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-2-carbaldehyde

Participants

Reaction Steps

2-bromo-4-fluorobenzaldehyde (1.53 g, 7.5 mmol) was reacted with (3,5-bis(trifluoromethyl)phenyl)boronic acid (2.3 g, 9 mmol) according to the procedure as described in Example 56, Step A to give the title compound as a white solid (2.34 g, 92%). The compound was characterized by the following spectroscopic data:

Provenance & Evidence