4-Hydroxyproline → HCID 118107625, compound

Participants

Reaction Steps

Ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (1.92 g, 3.81 mmol) was reacted with 4-hydroxypyrrolidine-2-carboxylic acid (0.5 g, 3.81 mmol) according to the procedure as described in Example 28 to give the title compound as a yellow solid (1.37 g, 65%). The compound was characterized by the following spectroscopic data:

Provenance & Evidence