Sodium Hydroxide → 2-(2-(4-(2-Bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-6-methyl-1,4-dihydropyrimidin-2-yl)thiazol-4-yl)acetic acid

Participants

Reaction Steps

Ethyl 4-(2-bromo-4-fluorophenyl)-2-(4-(2-methoxy-2-oxoethyl)thiazol-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate (1 g, 2 mmol) was reacted with sodium hydroxide (0.24 g, 6 mmol) according to the procedure as described Example 58, Step B to give the title compound as a yellow solid (0.87 g, 90%). The compound was characterized by the following spectroscopic data:

Provenance & Evidence