N-bromobutanimide → Ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(4-(2-(methyl amino)-2-oxoethyl)thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Participants

Reaction Steps

Ethyl 4-(2-bromo-4-fluorophenyl)-6-methyl-2-(4-(2-(methylamino)-2-oxoethyl)thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (1 g, 2 mmol) was reacted with NBS (0.39 g, 2.2 mmol) according to the procedure as described in Example 1, Step B to give the title compound as a yellow solid (0.63 g, 55%). The compound was characterized by the following spectroscopic data:

Provenance & Evidence