HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate → HCID 90043216, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate | HCID 59495567 | — |
| Reactant | HCID 90043304 | HCID 90043304 | — |
| Product | HCID 90043216 | HCID 90043216 | 44.3% |
Reaction Steps
Ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (0.34 g, 0.68 mmol) was reacted with 2-(morpholin-3-ylmethyl)propane-1,3-diol (0.12 g, 0.68 mmol) according to the procedure as described in Example 25, Step B to give the title compound as a yellow solid (0.18 g, 44%). The compound was characterized by the following spectroscopic data:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09340538B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-d4144c47ebb44eafa1661075fefd6ba2 |
| Source note | uspto-grants-2016_05 |