N-bromobutanimide → HCID 90042584, compound

Participants

Reaction Steps

Ethyl 4-(2-bromo-4-fluorophenyl)-6-methyl-2-(1,3,4-thiadiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (1.06 g, 2.5 mmol) was reacted with NBS (0.5 g, 2.8 mmol) according to the procedure as described in Example 1, Step B to give the title compound as a yellow solid (0.89 g, 71%). The compound was characterized by the following spectroscopic data:

Provenance & Evidence