Morpholine-2-carboxylic acid hydrochloride → 4-((6-(2-bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(1-methyl-1H-1,2,4-triazol-3-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholine-2-carboxylic acid

Participants

Reaction Steps

Ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(1-methyl-1H-1,2,4-triazol-3-yl)-1,4-dihydropyrimidine-5-carboxylate (1 g, 2 mmol) was reacted with morpholine-2-carboxylic acid hydrochloride (0.34 g, 2 mmol) according to the procedure as described in Example 1, Step C to give the title compound as a yellow solid (0.42 g, 38%). The compound was characterized by the following spectroscopic data:

Provenance & Evidence