Ammonium Chloride → Methyl 2-(3-carbamimidoyl-1H-1,2,4-triazol-1-yl)acetate hydrochloride

Participants

Reaction Steps

Ethyl 2-(3-cyano-1H-1,2,4-triazol-1-yl)acetate (2 g, 11.2 mmol) was reacted with sodium methoxide (0.85 g, 15.68 mmol) and ammonium chloride (0.89 g, 16.8 mmol) according to the procedure as described in Example 61, Step B to give the title compound as a white solid (1.35 g, 55%). The compound was characterized by the following spectroscopic data:

Provenance & Evidence