HCID 90042746, compound → HCID 73297046, compound

HRID 524739Notes

Reaction equation

Br[CH2:2][C:3]1[NH:8][C:7]([C:9]2[N:10]=[CH:11][S:12][CH:13]=2)=[N:6][CH:5]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[Cl:21])[C:4]=1[C:22]([O:24][CH2:25][CH3:26])=[O:23].Cl.[NH:28]1[CH2:33][CH2:32][O:31][CH:30]([CH2:34][CH2:35][C:36]([OH:38])=[O:37])[CH2:29]1>>[Cl:21][C:15]1[CH:16]=[C:17]([Cl:20])[CH:18]=[CH:19][C:14]=1[CH:5]1[N:6]=[C:7]([C:9]2[N:10]=[CH:11][S:12][CH:13]=2)[NH:8][C:3]([CH2:2][N:28]2[CH2:33][CH2:32][O:31][CH:30]([CH2:34][CH2:35][C:36]([OH:38])=[O:37])[CH2:29]2)=[C:4]1[C:22]([O:24][CH2:25][CH3:26])=[O:23]

Participants

Reactant 2

HCID 90042746HCID 90042746, compound

HCID 118107517HCID 118107517, compound

Product 1

HCID 73297046HCID 73297046, compoundYield 45%

Procedure

Ethyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(thiazol-4-yl)-1,4-dihydropyrimidine-5-carboxylate (0.73 g, 1.53 mmol) was reacted with 3-(morpholin-2-yl)propanoic acid hydrochloride (0.3 g, 1.53 mmol) according to the procedure as described in Example 28 to give the title compound as a yellow solid (0.38 g, 45%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record: ord-888d8936c1874d8f9df737444782475c
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09340538B2

Reaction notes

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