Ammonium Chloride → HCID 90043368, compound

HRID 524744Notes

Reaction equation

[O:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]#[N:7].C[O-].[Na+].[Cl-:11].[NH4+:12]>>[ClH:11].[O:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6](=[NH:12])[NH2:7]

Participants

Reactant 3

HCID 25517Ammonium Chloride

HCID 10942334Sodium Methoxide

HCID 198095131,3-Oxazole-2-carbonitrile

Product 1

HCID 90043368HCID 90043368, compound

Procedure

Oxazole-2-carbonitrile (0.94 g, 10 mmol) was reacted with sodium methoxide (0.81 g, 15 mmol) and ammonium chloride (0.96 g, 18 mmol) according to the procedure as described in Example 61, Step B to give the title compound as an offwhite solid (1.25 g, 70%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record: ord-28b793f77d9e4afd92a26e0eae49632d
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09340538B2

Reaction notes

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