N-bromobutanimide → HCID 178468569, compound

HRID 524754Notes

Reaction equation

HRID 524754 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:13]([CH3:20])[NH:12][C:11]([C:21]2[N:25]=[CH:24][NH:23][N:22]=2)=[N:10]1.C1C(=O)N([Br:33])C(=O)C1>C(Cl)(Cl)Cl>[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:13]([CH2:20][Br:33])[NH:12][C:11]([C:21]2[N:25]=[CH:24][NH:23][N:22]=2)=[N:10]1

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 178469216HCID 178469216, compound

Product 1

HCID 178468569HCID 178468569, compoundYield 45.2%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Ethyl 4-(2-bromo-4-fluorophenyl)-6-methyl-2-(1H-1,2,4-triazol-3-yl)-1,4-dihydropyrimidine-5-carboxylate (0.82 g, 2 mmol) was reacted with NBS (0.39 g, 2.2 mmol) in chloroform (40 mL) according to the procedure as described in Example 1, Step B to give the title compound as a yellow solid (0.44 g, 45%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record
ord-b19cd84417284ba08343363def44ba85
Source dataset
uspto-grants-2016_05
Patent number
US09340538B2

Reaction notes

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