2-Thiazolamine, 4-(trifluoromethyl)- → 4-(Trifluoromethyl)thiazole-2-carbonitrile

HRID 524761Notes

Reaction equation

HRID 524761 reaction equation
[F:1][C:2]([F:10])([F:9])[C:3]1[N:4]=[C:5](N)[S:6][CH:7]=1.[C:11]([Cu])#[N:12]>>[F:1][C:2]([F:10])([F:9])[C:3]1[N:4]=[C:5]([C:11]#[N:12])[S:6][CH:7]=1

Participants

3

Reactant 2

HCID 12014172-Thiazolamine, 4-(trifluoromethyl)-HCID 178418546HCID 178418546, compound

Product 1

HCID 595334344-(Trifluoromethyl)thiazole-2-carbonitrileYield 34%

Procedure

4-(trifluoromethyl)thiazol-2-amine (2.52 g, 15 mmol) was reacted with CuCN (2.95 g, 33 mmol) according to the procedure as described in Example 61, Step A to give the title compound as brown oil (0.90 g, 34%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record
ord-43a87e0be36e405fa7dd09c9c890e52d
Source dataset
uspto-grants-2016_05
Patent number
US09340538B2

Reaction notes

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