Ethyl Acetoacetate → Ethyl 4-(2,4-dichlorophenyl)-6-methyl-2-(4-(trifluoromethyl)thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

Participants

Reaction Steps

4-(trifluoromethyl)thiazole-2-carboximidamide acetate (0.38 g, 1.49 mmol) was reacted with 2,4-dichlorobenzaldehyde (0.26 g, 1.49 mmol) and ethyl 3-oxobutanoate (0.2 g, 1.49 mmol) according to the procedure as described in Example 1, Step A to give the title compound as a yellow solid (0.44 g, 64%). The compound was characterized by the following spectroscopic data:

Provenance & Evidence