Morpholine-3-carboxylic acid hydrochloride → 4-((6-(2,4-Dichlorophenyl)-5-(ethoxycarbonyl)-2-(4-(trifluoromethyl)thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholine-3-carboxylic acid
Reaction equation
Br[CH2:2][C:3]1[NH:8][C:7]([C:9]2[S:10][CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:13]=2)=[N:6][CH:5]([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=2[Cl:25])[C:4]=1[C:26]([O:28][CH2:29][CH3:30])=[O:27].Cl.[NH:32]1[CH2:37][CH2:36][O:35][CH2:34][CH:33]1[C:38]([OH:40])=[O:39]>>[Cl:25][C:19]1[CH:20]=[C:21]([Cl:24])[CH:22]=[CH:23][C:18]=1[CH:5]1[N:6]=[C:7]([C:9]2[S:10][CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:13]=2)[NH:8][C:3]([CH2:2][N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH:33]2[C:38]([OH:40])=[O:39])=[C:4]1[C:26]([O:28][CH2:29][CH3:30])=[O:27]Participants
3
Reactant 2
Product 1
Procedure
Ethyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(4-(trifluoromethyl)thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (0.1 g, 0.18 mmol) was reacted with morpholine-3-carboxylic acid hydrochloride (0.03 g, 0.18 mmol) according to the procedure as described in Example 1, Step C to give the title compound as a yellow solid (0.09 g, 80%). The compound was characterized by the following spectroscopic data:
Sources & evidence
- ORD record
- ord-0a7a958a4c44432e9b2728ee21542288
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09340538B2
Reaction notes
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