Morpholine-3-carboxylic acid hydrochloride → HCID 90043259, compound

HRID 524768Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:13]([CH2:20]Br)[NH:12][C:11]([C:22]2[S:23][C:24]([F:27])=[CH:25][N:26]=2)=[N:10]1.Cl.[NH:29]1[CH2:34][CH2:33][O:32][CH2:31][CH:30]1[C:35]([OH:37])=[O:36]>>[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH:9]1[N:10]=[C:11]([C:22]2[S:23][C:24]([F:27])=[CH:25][N:26]=2)[NH:12][C:13]([CH2:20][N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH:30]2[C:35]([OH:37])=[O:36])=[C:14]1[C:15]([O:17][CH2:18][CH3:19])=[O:16]

Participants

Reactant 2

HCID 45790954Morpholine-3-carboxylic acid hydrochloride

HCID 118107555HCID 118107555, compound

Product 1

HCID 90043259HCID 90043259, compoundYield 60%

Procedure

Ethyl 4-(2-bromo-4-fluorophenyl)-6-(bromomethyl)-2-(5-fluorothiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (0.63 g, 1.2 mmol) was reacted with morpholine-3-carboxylic acid hydrochloride (0.23 g, 1.4 mmol) according to the procedure as described in Example 28 to give the title compound as a yellowish solid (0.41 g, 60%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record: ord-c8c563ebf58b4f339a52a0c93cff8b3b
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09340538B2

Reaction notes

Loading…