Morpholine-3-carboxylic acid hydrochloride → HCID 118107566, compound

HRID 524771Notes

Reaction equation

HRID 524771 reaction equation
Br[CH2:2][C:3]1[NH:8][C:7]([C:9]2[S:10][C:11]([F:14])=[CH:12][N:13]=2)=[N:6][CH:5]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[Cl:22])[C:4]=1[C:23]([O:25][CH2:26][CH3:27])=[O:24].Cl.[NH:29]1[CH2:34][CH2:33][O:32][CH2:31][CH:30]1[C:35]([OH:37])=[O:36]>>[Cl:22][C:16]1[CH:17]=[C:18]([F:21])[CH:19]=[CH:20][C:15]=1[CH:5]1[N:6]=[C:7]([C:9]2[S:10][C:11]([F:14])=[CH:12][N:13]=2)[NH:8][C:3]([CH2:2][N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH:30]2[C:35]([OH:37])=[O:36])=[C:4]1[C:23]([O:25][CH2:26][CH3:27])=[O:24]

Participants

3

Reactant 2

HCID 45790954Morpholine-3-carboxylic acid hydrochlorideHCID 118107612HCID 118107612, compound

Product 1

HCID 118107566HCID 118107566, compoundYield 92.6%

Procedure

Ethyl 6-(bromomethyl)-4-(2-chloro-4-fluorophenyl)-2-(5-fluorothiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (0.2 g, 0.41 mmol) was reacted with morpholine-3-carboxylic acid hydrochloride (0.07 g, 0.41 mmol) according to the procedure as described in Example 1, Step C to give the title compound as a yellow solid (0.2 g, 90%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record
ord-35791ef85bf843e3b6a3058e935fd15b
Source dataset
uspto-grants-2016_05
Patent number
US09340538B2

Reaction notes

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