Ethyl 1-benzyl-4-methylpiperazine-2-carboxylate → Ethyl 4-methylpiperazine-2-carboxylate

HRID 524779Notes

Reaction equation

HRID 524779 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH:9]1[C:15]([O:17][CH2:18][CH3:19])=[O:16])C1C=CC=CC=1>[Pd]>[CH3:14][N:11]1[CH2:12][CH2:13][NH:8][CH:9]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:10]1

Participants

3

Reactant 1

HCID 10563447Ethyl 1-benzyl-4-methylpiperazine-2-carboxylate

Product 1

HCID 12558522Ethyl 4-methylpiperazine-2-carboxylateYield 82%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Ethyl 1-benzyl-4-methylpiperazine-2-carboxylate (11.54 g, 44 mmol) was reacted with Pd—C (10%, 1 g) according to the procedure as described in Example 34, Step C to give the title compound as colorless oil (6.2 g, 82%). The compound was characterized by the following spectroscopic data:

Sources & evidence

ORD record
ord-ec1f039cb0be49b58eca347e4a31fd6a
Source dataset
uspto-grants-2016_05
Patent number
US09340538B2

Reaction notes

Loading…